Nepramel works by reducing the amount of acid that your stomach produces. It is used to treat the following conditions including Gastro-oesophageal reflux disease (GORD), Ulcers in the stomach or upper part of the gut (intestine) that are infected with bacteria called Helicobacter pylori, Stomach ulcers caused by medicines called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), Too much acid in the stomach caused by a growth in the pancreas (Zollinger-Ellison syndrome) and Prolonged treatment after prevention of rebleeding of ulcers with intravenous esomeprazole.